Immune and IgG Profiles for 696 Oral Lichen Planus Patients

696 OLP patients were enrolled in a retrospective cross-sectional study analyzing immune cell subsets and food-specific IgG antibodies. Peripheral lymphocyte subsets were quantified by flow cytometry, and serum levels of antibodies against 14 food antigens and inflammatory mediators were measured by ELISA. The data supports a 'Two-Hit' pathogenic model linking T-cell deficiency and IgG responses to erosive disease.

Use Cases

• Identify high-risk patient phenotypes based on combined immune-suppressed and IgG-positive status.
• Investigate associations between specific lymphocyte subsets (e.g., CD3+, CD4+, NK cells) and clinical disease severity.
• Analyze correlations between food-specific IgG antibodies (e.g., against eggs) and systemic inflammatory markers like IL-6 and CRP.
• Build predictive models for erosive OLP using features like disease duration, T-cell counts, and cytokine levels.
• Profile demographic differences in immune response by stratifying data by age and gender.

Strengths

• Data from 696 patients provides a substantial cohort for analysis.
• Includes measurements for multiple immune cell types, 14 food-specific IgG antibodies, and 5 inflammatory mediators.
• Patients are stratified by key clinical and demographic variables, including erosive vs. non-erosive OLP.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the single retrospective study design.

Provenance

Source

Author Yanjie Yang, shared via figshare.

Collection Method

Retrospective cross-sectional study using flow cytometry and ELISA.

Freshness

Last updated 2026-05-11 05:28:46; freshness should be verified.