Systematic Review on Immune Dysregulation in Tuberculosis-Diabetes Comorbidity

81 studies published between 1974 and 2023 were synthesized to examine how diabetes mellitus alters tuberculosis pathogenesis. This 20.5 KB document, authored by Aminat Y. Saula and last updated in April 2026, is a systematic review summarizing immunological mechanisms linking the two diseases. The findings highlight diabetes as a key immunometabolic modifier of TB and suggest potential therapeutic strategies.

Use Cases

• Identify key immune pathways dysregulated in TB-DM comorbidity based on the review's synthesis of innate and adaptive immune responses.
• Compare immunological profiles between active TB with DM and latent TB infection with DM based on the distinct immune profiles mentioned.
• Investigate the role of pre-diabetes in TB progression based on the emerging evidence for intermediate hyperglycemia.
• Inform the design of host-directed therapeutic strategies based on the conclusion's suggestion for metabolic optimization.

Strengths

• Systematic methodology covering 81 eligible studies identified from a 49-year period (1974-2023).
• Focus on a high-impact clinical problem: the comorbidity of two major global diseases.
• Clear registration with PROSPERO (CRD42023431040), indicating a structured review process.

Limitations

• The dataset is a 20.5 KB DOCX file, indicating a limited textual summary rather than raw experimental data.
• Row count and column-level documentation are absent; the document's internal structure must be inspected after download.
• Heterogeneity in study designs and metabolic status of subjects, as noted in the results, may complicate direct comparisons.

Provenance

Source

figshare

Collection Method

Systematic review of published literature.

Time Range

Studies published from 1974 to May 31, 2023.

Freshness

Last updated 2026-04 23 04:21:47

Geography

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