Central Obesity Impact on Esophageal Motility and Mucosal Barrier

A clinical study of 185 patients stratified by visceral-to-subcutaneous fat ratio (V/S) investigates the impact of central obesity on esophageal function. It includes high-resolution manometry and 24-hour pH-impedance parameters, with GERD prevalence ranging from 22.92% to 54.35% across quartiles. The analysis correlates V/S with metrics like lower esophageal sphincter pressure, acid exposure time, and mean nocturnal baseline impedance.

Use Cases

• Analyze the correlation between the visceral-to-subcutaneous fat ratio (V/S) and acid exposure time (AET) or DeMeester score (DMS) across patient quartiles.
• Model the relationship between V/S and lower esophageal sphincter (LES) resting pressure or esophagogastric junction contractile integral (EGJ-CI) while adjusting for confounders like Hiatal Hernia.
• Investigate the association between mean nocturnal baseline impedance (MNBI) Z3-Z6 and GERD prevalence, which increased from 22.92% to 54.35% across V/S groups.
• Examine intergroup differences in gender distribution and BMI across the four V/S quartiles defined in the study.

Strengths

• Includes data from 185 patients, providing a substantive clinical cohort for analysis.
• Contains multiple specific physiological metrics, including LES resting pressure, EGJ-CI, AET, DMS, and MNBI Z3-Z6.
• Patients are stratified into four distinct quartiles based on a calculated V/S ratio, enabling comparative analysis.
• Study design incorporates adjustment for several confounders like Hiatal Hernia and Bolus Clearance Time in regression models.

Limitations

• The dataset is small in file size (13.8 KB), suggesting it contains summary or aggregated results rather than raw patient-level data.
• Specific column names and the raw tabular data structure are not provided, limiting direct analytical use.
• As a retrospective study, it may be subject to selection bias and unmeasured confounding factors.

Provenance

Source

Jiang Guidong via figshare.

Collection Method

Retrospective clinical study combining fiberoptic gastroduodenoscopy, high-resolution manometry, 24-h pH-impedance monitoring, and non-contrast abdominal CT scans. V/S ratio calculated using the TotalSegmentator tool.

Freshness

Last updated in March 2026, indicating recent analysis.