Influenza Vaccination Outcomes in High-Risk Populations: An Umbrella Review

An umbrella review synthesizing 14 systematic reviews and meta-analyses on influenza vaccination effectiveness and safety in populations at high risk of cardiovascular and respiratory complications. The evidence base covers more than 230 million participants, with findings assessed for methodological quality and certainty. The document was authored by Chengyan Jin and uploaded to figshare in May 2026.

Use Cases

• Assessing the association between influenza vaccination and major adverse cardiovascular events based on the review's narrative synthesis.
• Evaluating evidence certainty for vaccination reducing COPD exacerbations based on the GRADE framework application.
• Identifying research gaps for stroke and respiratory outcomes based on the reported moderate to low certainty evidence.
• Analyzing the safety profile of influenza vaccination based on the review's finding of no clear increase in serious adverse events.

Strengths

• Evidence synthesis is based on 14 systematic reviews and meta-analyses.
• The underlying evidence base covers more than 230 million participants.
• Methodological quality was assessed using AMSTAR-2 and evidence certainty using GRADE.
• Review overlap was formally assessed using citation matrices and corrected covered area (CCA).

Limitations

• The dataset is a 16.9 KB DOCX document, indicating a limited scope of raw data.
• Column-level documentation is absent; field semantics must be inferred after download.
• The primary data consists of review summaries; original participant-level data is not included.

Provenance

Source

figshare

Collection Method

Umbrella review of systematic reviews and meta-analyses identified through PubMed, Embase, and the Cochrane Library.

Time Range

Reviews from database inception to December 1, 2025.

Freshness

Last updated 2026-05-26 06:02:04