Innate Immune Cell Profiles from Hypertensive and Normotensive Male Subjects

figshare admin frontiersin published a dataset on 2026-04-16 containing mass cytometry, flow cytometry, and single-cell RNA sequencing data from a study of natural killer (NK) cells in hypertension. The data likely includes immune cell profiles from peripheral blood mononuclear cells of 20 male subjects in a discovery cohort and 16 in a validation cohort. The study identified a specific reduction of the CD57+CD62L+CD161+ NK cell subpopulation in hypertensive males.

Use Cases

• Validate the reduction of CD57+CD62L+CD161+ NK cells in hypertension based on the described cytometry data.
• Analyze transcriptional heterogeneity within the identified NK subpopulation based on the single-cell RNA sequencing results.
• Investigate the imbalance between KLRC2-high Adaptive and FCER1G-high Cytotoxic NK subsets described in the results.
• Study associations between IL-15 signaling and NK cell survival/apoptosis factors based on the mechanistic findings.

Strengths

• Data is validated across two independent cohorts totaling 36 male subjects.
• Multi-modal profiling includes high-dimensional mass cytometry, flow cytometry, and single-cell RNA sequencing.
• Dataset is openly available under a CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is limited to male subjects, which may restrict generalizability.

Provenance

Source

figshare admin frontiersin

Collection Method

High-dimensional mass cytometry (CyTOF), full-spectrum flow cytometry, and single-cell RNA sequencing of sorted cells.

Time Range

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Freshness

Last updated 2026-04-16 05:25:51; freshness should be verified.

Geography

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