TP53 H179 Zinc-Binding Variants: Molecular Dynamics Analysis Across NSCLC Subtypes

TP53 gene mutations were present in 50% of lung adenocarcinoma and 81% of lung squamous cell carcinoma cases analyzed. This dataset contains a research document analyzing the structural and functional impact of specific mutations at the His179 residue in the p53 protein's zinc-binding motif, using data from The Cancer Genome Atlas and molecular dynamics simulations. The document was authored by Ankur Datta and last updated in April 2026.

Use Cases

• Study the structural impact of specific TP53 mutations based on molecular dynamics simulations described in the document.
• Analyze mutation frequency and type in NSCLC cohorts based on the TCGA mutational profiles referenced.
• Investigate the relationship between zinc-binding motif perturbations and protein stability based on the conformational and binding affinity analyses.
• Compare mutation-induced structural plasticity in specific protein loops (L1, L2) based on the results discussed.

Strengths

• Analysis includes 616 LUAD and 544 LUSC individuals from TCGA.
• Focuses on a specific, underexplored structural site (His179) with five identified variants.
• License is CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• The dataset is a 12.9 KB DOCX file, suggesting limited scope and no structured data tables.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Analysis of TCGA mutational profiles combined with static structural analysis and molecular dynamics simulations.

Time Range

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Freshness

Last updated 2026-04-10 05:59:25; freshness should be verified.

Geography

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