Integrated Multi-Omics Data for Sepsis Immune Dysregulation and Therapy

Integrated multi-omics datasets from a sepsis study delineating immune cell dynamics and dysregulated pathways. The data likely contains results from scRNA-seq, miRNA-seq, and blood/lung RNA-seq analyses, supporting the design and validation of dual-pathway small-molecule therapies. The dataset was authored by Jiawen Duan and last updated on 2026-05-15.

Use Cases

• Analyze immune cell population shifts in sepsis based on the described expansion of pro-inflammatory myeloid cells and depletion of lymphoid cells.
• Validate pathway dysregulation signatures based on the mentioned inflammatory cascades and Hippo/Wnt regenerative pathways.
• Assess therapeutic efficacy metrics based on the described changes in cytokine levels (e.g., Il1b, Il6, Il10) and survival rates.
• Investigate multi-organ injury markers based on the described amelioration of organ dysfunction in sepsis models.

Strengths

• Dataset is openly licensed under CC-BY-4.0.
• The underlying study validated findings in both in vitro and in vivo sepsis models.
• The description provides specific molecular targets and outcome measures, such as cytokine levels and a survival improvement from 20% to 70%.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 10.1 KB, indicating limited scope or summary-level data.

Provenance

Source

figshare

Collection Method

Integrated multi-omics analysis (scRNA-seq, miRNA-seq, blood/lung RNA-seq) from a sepsis research study.

Freshness

Last updated 2026-05-15 04:22:31; freshness should be verified.