Sivelestat Mechanisms in Myocarditis: Pharmacology and Mouse Model Data

Ruguo Ren published a dataset on figshare in April 2026 detailing the multi-target mechanisms of the neutrophil elastase inhibitor Sivelestat in experimental autoimmune myocarditis. The 12.0 KB XLSX file likely contains results from network pharmacology, molecular docking, and in vivo mouse model experiments. Data includes computational target identification, cytokine levels, cardiac function measurements, and pathway analysis from a study with 6 mice per group.

Use Cases

• Validate network pharmacology predictions based on shared targets between Sivelestat and myocarditis.
• Analyze dose-response relationships based on Sivelestat administration at 50, 100, and 200 mg/kg/day.
• Correlate inflammatory markers like serum IL-1β, IL-6, and TNF-α with cardiac function parameters.
• Investigate PI3K-Akt signaling pathway activation based on Western blot data for p-Akt, Bcl-2, and cleaved caspase-3.
• Study NETosis inhibition mechanisms based on Cit-H3 and neutrophil elastase immunofluorescence data.

Strengths

• Dataset integrates computational (41 potential targets) and experimental validation from a controlled mouse study.
• Includes specific quantitative results such as molecular docking binding affinity for PTGS2 (-9.0 kcal/mol).
• Measures multiple endpoints: cardiac function (echocardiography), serum cytokines, histopathology, and apoptosis.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• Data scale is limited to a single experimental study with a small sample size (n=6 per group).
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare

Collection Method

Data generated from an integrated pharmacology study combining network analysis, molecular docking, and experimental validation in a mouse model of experimental autoimmune myocarditis.

Freshness

Last updated 2026-04-30 04:17:52; freshness should be verified.