RGS4 Expression in SF-1 Lineage Pituitary Tumors: Single-Cell and Bulk RNA-Seq Data

An integrated analysis of single-cell and bulk RNA sequencing data from Steroidogenic Factor-1 (SF-1) lineage Pituitary Neuroendocrine Tumors (PitNETs) identifies a high-RGS4 expression subgroup linked to proliferation. The 2.6 MB Excel file, authored by Changxi Han and last updated in April 2026, contains results from functional experiments demonstrating RGS4's role in promoting tumor cell growth via p53 destabilization. This dataset is shared under a CC-BY-4.0 license on figshare.

Use Cases

• Identify molecular subgroups within pituitary tumors based on integrated single-cell and bulk transcriptomic profiles mentioned in the description
• Validate the correlation between RGS4 expression and tumor proliferation metrics like size and MIB-1 index described in the results
• Investigate the RGS4-p53 axis as a potential therapeutic target for a subset of PitNETs, as highlighted in the conclusion

Strengths

• Dataset is based on an integrated analysis of both single-cell and bulk RNA sequencing data, as described in the methods.
• Functional validation of the top candidate gene (RGS4) is detailed using gain/loss-of-function approaches and pharmacological inhibition.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale modeling.
• The dataset is small (2.6 MB), suggesting it contains summary or processed results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Integrated analysis of single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic datasets from SF-1 lineage PitNETs, followed by functional experiments in cell lines.

Freshness

Last updated 2026-04-22 05:49:43; freshness should be verified.