Lactate Dehydrogenase-to-Albumin Ratio and Adverse Outcomes in 1,084 HFrEF/HFmrEF Patients

A retrospective cohort study of 1,084 hospitalized patients with heart failure with reduced or mildly reduced ejection fraction (HFrEF/HFmrEF). The dataset, authored by Yaping Zhang and shared on figshare, investigates the association between the lactate dehydrogenase-to-albumin ratio (LAR) and adverse outcomes over a mean follow-up of 29.3 months. It was last updated on April 27, 2026.

Use Cases

• Predicting heart failure-related readmission risk based on the lactate dehydrogenase-to-albumin ratio (LAR).
• Modeling all-cause mortality risk in heart failure patients using baseline LAR levels.
• Assessing the incremental predictive value of LAR for composite clinical endpoints using C-index, NRI, and IDI metrics.
• Conducting subgroup and sensitivity analyses to evaluate the robustness of biomarker associations.

Strengths

• Includes data from 1,084 patients, providing a substantial clinical cohort.
• Features a mean follow-up period of 29.3 months for longitudinal outcome tracking.
• Analysis includes multiple statistical methods (Cox regression, Kaplan-Meier, Fine-Grey model) as described.
• Shared under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect temporal and institutional bias inherent to a single retrospective study.

Provenance

Source

Yaping Zhang via figshare.

Collection Method

Retrospective cohort study of hospitalized patients.

Time Range

Mean follow-up of 29.3 months (specific study dates not provided).

Freshness

Last updated 2026-04-27 10:39:33; freshness should be verified.