NHANES 2005-2008 Blood Lead Levels and Retinal Vein Occlusion Risk

Shuai Yang published a dataset on figshare in 2026 linking blood lead levels to retinal vein occlusion (RVO). The data includes results from a multivariate logistic regression analysis of 5,415 participants from the 2005-2008 NHANES survey, where 32 had RVO. It also contains RNA sequencing results from lead-treated endothelial cells, identifying 166 differentially expressed genes.

Use Cases

• Assessing the association between blood lead concentration and retinal vein occlusion risk based on NHANES survey data.
• Investigating transcriptomic effects of lead exposure on endothelial cells based on RNA sequencing results.
• Validating the role of specific genes like PRICKLE4 and PLCXD1 in lead-induced endothelial dysfunction.
• Performing functional enrichment analysis on differentially expressed genes to identify disrupted pathways like Wnt signaling.

Strengths

• Analysis is based on a large, nationally representative sample of 5,415 participants from NHANES.
• Includes both epidemiological findings (significant p-values for lead association) and molecular validation (qRT-PCR confirmation of gene expression).
• Dataset is licensed as CC-BY-4.0, allowing for open reuse and redistribution.

Limitations

• Row count and column-level documentation are unknown, which may limit suitability assessment.
• The dataset is very small (12.2 KB), suggesting it contains summary or analysis results rather than raw participant-level data.
• Freshness should be verified as the last update date is in the future (2026-05-12).

Provenance

Source

National Health and Nutrition Examination Survey (NHANES) 2005-2008.

Collection Method

Multivariate logistic regression analysis of survey data combined with laboratory RNA sequencing of treated HUVECs.

Time Range

2005-2008 for the NHANES participant data.

Freshness

Last updated 2026-05-12 05:42:56; freshness should be verified.

Geography

United States (NHANES survey).