Long-term Survival Outcomes for T4N0-3M0 Esophageal Cancer Treatments

A retrospective cohort study compares overall survival (OS) and progression-free survival (PFS) for 490 patients with T4N0-3M0 esophageal squamous cell carcinoma treated with surgery plus adjuvant chemoradiotherapy (S+CRT) or definitive chemoradiotherapy (dCRT). The analysis includes data from a single institution collected between January 2011 and December 2018. Propensity score matching was performed on a subset of 219 patients.

Use Cases

• Compare overall survival (OS) and progression-free survival (PFS) outcomes between the S+CRT and dCRT treatment groups.
• Apply propensity score matching (PSM) to adjust for confounding variables when analyzing the 490 patient cohort.
• Analyze long-term prognosis for patients with T4N0-3M0 stage esophageal squamous cell carcinoma based on treatment modality.

Strengths

• Analysis is based on 490 patient records from a defined clinical cohort.
• Includes results from a propensity score matched subset of 219 patients (138 dCRT, 81 S+CRT).
• Reports statistically significant P-values (e.g., P=0.000, 0.003) for survival outcome comparisons.

Limitations

• The dataset is small in scale (158.0 KB), suggesting it contains summary or tabulated results, not granular patient-level data.
• As a single-center retrospective study, findings may have limited generalizability due to institutional practices and patient population.
• The primary data format is a DOC file, which is not ideal for direct computational analysis and may require extraction.

Provenance

Source

Single-center retrospective cohort study by author Shiwang Wen, shared via figshare.

Collection Method

Retrospective review of patient records meeting specific clinical criteria.

Time Range

January 2011 to December 2018.

Freshness

Data covers patients treated up to December 2018; the record was last updated in March 2026.

Geography

Patients treated at a single, unspecified institution; geographic coverage is null.