Table 3: Proteomic and Genetic Data for Neurofibromatosis Types 1 and 2 Tumor Analysis

A study by Erxing Tao, last updated in May 2026, investigates common molecular mechanisms in Neurofibromatosis types 1 and 2. The dataset likely contains results from mutational and proteomic analyses of 15 patient samples, including differential protein expression and loss of heterozygosity data for the candidate gene EPB41L3. The data is shared under a CC-BY-4.0 license via figshare.

Use Cases

• Identify common differentially expressed proteins in NF1 and NF2 tumors based on the proteomic profiles mentioned.
• Analyze the correlation between EPB41L3 loss of heterozygosity and tumor type based on the reported LOH percentages.
• Investigate the relationship between EPB41L3 expression and key proteins Merlin and Neurofibromin based on the Western blot analysis results.
• Model the impact of EPB41L3 on cell proliferation and viability based on the functional assays described.

Strengths

• Includes data from 15 patient samples, as stated in the methods.
• Reports specific counts of differentially expressed proteins (159 in NF1, 180 in NF2).
• Provides quantified loss of heterozygosity results for EPB41L3 (60% in NF1, 20% in NF2).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 103.3 KB, indicating limited scope.

Provenance

Source

figshare, author Erxing Tao.

Collection Method

Generated from mutational analysis (Sanger sequencing), proteomic profiling (TMT-labeled spectrometry), and protein expression assays (Western blot/immunofluorescence).

Time Range

The study period is not specified.

Freshness

Last updated 2026-05-20 04:33:15; freshness should be verified.

Geography

Geographic origin of samples is not specified.