Table 3_LRP1 as a potential diagnostic and immunomodulatory target in endometriosis: evide

Chengmao Xie published a dataset on figshare in April 2026 supporting research on low-density lipoprotein receptor-related protein 1 (LRP1) as a diagnostic and immunomodulatory target in endometriosis. The 11.8 KB XLSX file contains results from integrated multi-omics analyses of three GEO datasets, identifying 1,404 differentially expressed genes and 30 hub genes. Findings include a causal relationship between LRP1 and M2 macrophage infiltration and validation of LRP1 expression in ectopic lesions.

Use Cases

• Training diagnostic models for endometriosis based on the 30 identified hub genes.
• Analyzing immune cell infiltration correlations based on the reported strong positive correlation between LRP1 and M2 macrophages.
• Investigating cell-cell communication pathways in endometriosis based on the described MIF signaling pathway and CD74/CXCR4 interactions.
• Validating causal relationships in disease pathogenesis using the provided Mendelian randomization analysis results.

Strengths

• Integrated analysis of three GEO datasets (GSE7305, GSE11691, GSE25628) for cross-validation.
• Identified 1,404 differentially expressed genes and 30 hub genes through machine learning algorithms.
• Findings validated at both mRNA and protein levels in ectopic lesions.
• Includes single-cell RNA sequencing data demonstrating cell-type-specific LRP1 expression.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The dataset is very small (11.8 KB), indicating limited scope, likely containing summary results rather than raw sequencing data.

Provenance

Source

figshare, author Chengmao Xie.

Collection Method

Integrated multi-omics analysis merging three public GEO datasets, using WGCNA and machine learning, supplemented by single-cell RNA sequencing and experimental validation.

Time Range

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Freshness

Last updated 2026-04-15 04:22:11; freshness should be verified.

Geography

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