Bordetella Pertussis Macrolide Resistance Trajectories Under Erythromycin Exposure

Table 3_Macrolide resistance trajectories across three Bordetella pertussis genetic backgrounds under stepwise erythromycin exposure.xlsx is a dataset by Kaichong Jiang, last updated on 2026-04-17. It contains data from an in vitro study tracking resistance evolution in three clinical isolates of Bordetella pertussis. The dataset includes phenotypic and genomic measurements from stepwise antibiotic exposure experiments.

Use Cases

• Modeling antibiotic resistance trajectories based on genetic background and phenotypic readouts.
• Analyzing correlations between genomic alterations and minimum inhibitory concentration (MIC) changes.
• Comparing growth and biofilm formation differences across bacterial lineages under antibiotic pressure.
• Investigating associations between resistance variants and virulence/metabolism factor expression measured by ELISA.

Strengths

• Data is derived from whole-genome sequencing of three distinct clinical isolates, providing genetic context.
• Includes multiple phenotypic readouts: antimicrobial susceptibility testing, growth assays, biofilm assays, and ELISA measurements.
• Dataset is small (10.8 KB), facilitating quick initial inspection and analysis.

Limitations

• Row count and specific column definitions are unknown, limiting suitability assessment.
• The dataset's scale is limited to three genetic backgrounds, which may not represent the full diversity of Bordetella pertussis.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Kaichong Jiang via figshare.

Collection Method

Data generated from stepwise erythromycin induction experiments on three clinical Bordetella pertussis isolates, with tracking via whole-genome sequencing and phenotypic assays.

Freshness

Last updated 2026-04-17 05:20:56; freshness should be verified.