Systematic Review of Managed Entry Agreements for Pharmaceuticals, 96 Studies

96 studies from a systematic review map the global landscape of Managed Entry Agreements (MEAs) for pharmaceuticals. The review, conducted by Hussain Abdulrahman Al-Omar and published in 2026, synthesizes evidence on MEA frameworks, governance, and implementation challenges. It identifies a significant evidence gap for Middle Eastern and low-income countries.

Use Cases

• Identifying common barriers to MEA implementation based on the documented inefficiencies in regulatory frameworks and data infrastructure.
• Analyzing geographic evidence gaps in MEA research based on the reported focus on European and North American systems.
• Studying stakeholder representation in health technology assessment based on the noted underrepresentation of academia and civil society.
• Investigating payment models for Advanced Therapy Medicinal Products (ATMPs) based on the minority of studies focusing on this theme.

Strengths

• Based on a systematic review of 96 studies following PRISMA guidelines.
• Provides quantified analysis of key barriers, such as inefficient regulatory frameworks (42% of studies) and data infrastructure limitations (41%).
• Clearly documents the geographic distribution of the evidence base, with 43% of studies focused on Europe.

Limitations

• The dataset is a 671.3 KB DOCX document, suggesting a limited scope primarily containing the review's narrative synthesis.
• Row count and column-level documentation are absent; the structure and granularity of any underlying data tables are unknown.
• Data may reflect publication bias inherent to the systematic review's source databases (MEDLINE and EMBASE).

Provenance

Source

Hussain Abdulrahman Al-Omar

Collection Method

Systematic review following PRISMA guidelines, searching MEDLINE and EMBASE from inception to March 2025.

Time Range

Literature review covering studies from database inception to March 2025.

Freshness

Last updated 2026-04-20 05:23:19

Geography

Global, with a noted focus on European (43%) and North American (28%) systems.