Maternal Probiotic Supplementation Outcomes From 18 Systematic Reviews

2025 analysis re-evaluates evidence from 18 systematic reviews on maternal probiotic use and offspring health. The review encompasses 62 specific offspring-related outcomes, with summary effects re-estimated using random-effects models. Wenrui Sun authored this 184.7 KB Excel file summarizing meta-analysis results.

Use Cases

• Analyze GRADE certainty ratings and AMSTAR-2 quality appraisals across the 18 included systematic reviews.
• Examine re-estimated summary effects, such as risk ratios (RR) and standardized mean differences (SMD), for outcomes like offspring eczema risk.
• Investigate the credibility criteria ratings applied to statistically significant associations from the umbrella review.
• Compare narrative summaries for outcomes from single primary studies or with unextractable data against meta-analysis results.

Strengths

• Synthesizes evidence from 18 systematic reviews, providing a consolidated view of the research field.
• Re-analysis encompasses 62 specific offspring-related outcomes, offering quantitative breadth.
• Includes quality appraisal via AMSTAR-2 and certainty grading via GRADE for methodological transparency.
• Clear provenance with PROSPERO systematic review registration (CRD420251120972).

Limitations

• Dataset scope is limited to summary-level evidence from reviews; contains no raw patient-level or primary study data.
• Small physical scale at 184.7 KB, indicating a condensed summary table rather than an extensive primary data collection.
• Findings are constrained by the underlying reviews' publication dates, with searches current only to June 15, 2025.

Provenance

Source

figshare, authored by Wenrui Sun.

Collection Method

Umbrella review with re-analysis of systematic reviews and meta-analyses from PubMed, Embase, CINAHL, Web of Science, and Cochrane Library.

Time Range

Literature search up to June 15, 2025.

Freshness

Last updated March 26, 2026.

Geography

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