Melanoma Stem Cell and Macrophage Interaction Data from In Vitro Models

Martina Anselmi's dataset contains experimental results on how melanoma stem cells reprogram macrophages, affecting tumor stemness and immune response. The data likely includes transcriptomic profiles, secretory profiles, and clinical survival associations from an independent melanoma patient cohort. It was last updated on June 2, 2026, and is shared under a CC-BY-4.0 license.

Use Cases

• Training models to predict macrophage phenotype based on stem cell signaling factors mentioned in the description.
• Analyzing associations between stem cell-educated macrophage gene signatures and patient survival outcomes referenced in the results.
• Studying the impact of conditioned media on natural killer (NK) cell cytotoxicity as described in the experimental methods.

Strengths

• Data is derived from standardized in vitro models using two melanoma cell lines (A375 and WM115).
• Includes exploratory clinical relevance analysis from an independent melanoma patient cohort.
• File size is 809.1 KB, indicating a focused and likely manageable dataset.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• Data is from controlled in vitro models; physiological relevance may require further validation as noted in the conclusions.

Provenance

Source

figshare, author Martina Anselmi.

Collection Method

Generated from melanosphere cultures, THP-1 monocyte differentiation, RNA-seq, and analysis of a clinical cohort.

Freshness

Last updated 2026-06-02 05:43:48.