CD44 and APP Causal Risk Factors in Head and Neck Cancer via Lactylation-MR Analysis

212 lactylation-associated differentially expressed genes were identified from three transcriptomic cohorts totaling 53 HNSCC patients and 53 controls. A Mendelian randomization analysis established CD44 and APP as genetic causal risk factors for head and neck squamous cell carcinoma. The dataset, authored by Xi Zhang and last updated in May 2026, presents results from this integrated lactylation-proteomics and genomics study.

Use Cases

• Validate causal gene candidates for HNSCC based on Mendelian randomization results.
• Investigate links between protein lactylation and immune cell infiltration patterns described in the functional profiling.
• Correlate gene expression of CD44 and APP with mTOR signaling and ECM pathway activation.
• Replicate the integrative analytical framework merging lactylation proteomics, transcriptomics, and genetic instruments.

Strengths

• Results are validated using an independent The Cancer Genome Atlas dataset and HNSCC cell lines.
• Analysis integrates data from three public transcriptomic cohorts and a systematically compiled set of 2,124 lactylation-related genes.
• The dataset is licensed under CC-BY-4.0, permitting broad reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (24.4 KB), indicating it likely contains summary results rather than raw multi-omics data.

Provenance

Source

figshare

Collection Method

Integrative analysis merging lactylation proteomics, transcriptomics, and Mendelian randomization using public cohorts and GWAS summary statistics.

Freshness

Last updated 2026-05-28 09:04:45; freshness should be verified.