Metabolic Profiles of PCOS-like Endometrial Organoid Fluids

9.4 KB of metabolomics data compares Intra-Organoid Fluid (IOF) and Extra-Organoid Fluid (EOF) from three endometrial organoid models simulating polycystic ovary syndrome. The dataset highlights altered amino acid metabolism, specifically glutamine changes in EOF, and fatty acid changes in IOF. Author Haoxuan Yang created this resource to investigate metabolic markers related to implantation failure in PCOS.

Use Cases

• Analyze glutamine concentration differences between Intra-Organoid Fluid (IOF) and Extra-Organoid Fluid (EOF) to model PCOS-related endometrial dysregulation.
• Correlate fatty acid metabolite levels in IOF with simulated androgen exposure levels across the three organoid cases.
• Identify metabolic pathway alterations by comparing amino acid profiles in EOF from the high-androgen model to control conditions.
• Screen for potential metabolic intervention targets by examining the dataset's highlighted changes in glutamine and fatty acid metabolism.

Strengths

• Data is derived from a controlled in vitro model using three distinct endometrial organoid cases, allowing for comparative analysis.
• Metabolomic profiling was performed via high-throughput quantitative methods on separated IOF and EOF samples.
• The dataset is focused on a specific biological question regarding glutamine's role in PCOS-related implantation failure.
• Available under a permissive CC BY 4.0 license for open reuse and sharing.

Limitations

• The dataset is very small at 9.4 KB, indicating limited scope and sample size with only three organoid cases.
• As an in vitro model, findings may not directly translate to in vivo human endometrial physiology.
• Specific column names, row counts, and raw numerical data are not provided in the input description.

Provenance

Source

Figshare, authored by Haoxuan Yang.

Collection Method

Metabolomic analysis of fluid from endometrial organoids constructed from clinically healthy tissue and treated with estradiol and testosterone to simulate PCOS-like characteristics.

Freshness

Last updated on 2026-03-25.