Mouse Lung Proteome Data from Millettia Speciosa Asthma Treatment Study

179 differentially expressed proteins identified in a mouse model of allergic asthma treated with the herb Millettia speciosa. The dataset includes proteomic analysis revealing complete suppression of the eosinophil-recruiting chemokine CCL24 and functional enrichment results for pathways like complement cascades and PPAR signaling. Author Hangrui Yang published the data on figshare in June 2026 under a CC-BY-4.0 license.

Use Cases

• Identify protein biomarkers for asthma treatment response based on the 179 differentially expressed proteins.
• Investigate the role of the CCL24-eosinophil axis in allergic inflammation based on the described chemokine suppression.
• Analyze immunometabolic pathway modulation based on the described enrichment in complement, lipid transport, and PPAR signaling.
• Validate hub protein networks in lung tissue based on described key proteins like Alb, Apoe, and Apoa1.

Strengths

• Proteomic analysis identified 179 differentially expressed proteins with statistical significance.
• Findings are integrated with cytokine profiling data from bronchoalveolar lavage fluid, showing reductions in IgE, IL-4, IL-5, and IL-6.
• Dataset is openly available under a permissive CC-BY-4.0 license.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The 3.1 MB file size suggests a relatively small-scale dataset.
• The mechanistic link to the gut-lung axis is noted as hypothetical within the study description.

Provenance

Source

figshare

Collection Method

High-resolution data-independent acquisition (DIA) lung proteomics from an ovalbumin-induced mouse model of allergic asthma.

Freshness

Last updated 2026-06-03 07:42:25.