Pediatric Asthma-Obesity Comorbidity Circulating miRNA Profiles

Circulating microRNA expression profiles from whole blood samples of 43 children across four groups: normal weight with asthma, overweight/obese with asthma, overweight/obese without asthma, and normal weight without asthma. The data was collected by Harshita Shailesh and published on figshare in May 2026. Profiles were assessed using the NanoString nCounter platform to identify shared miRNA signatures.

Use Cases

• Identify biomarker candidates for asthma stratification based on shared miRNA signatures.
• Investigate molecular pathways linking obesity and asthma based on target gene analysis of dysregulated miRNAs.
• Correlate miRNA expression with clinical parameters like neutrophil counts and lung function.
• Explore potential therapeutic targets in IL-4, IL-13, and PIP3/AKT signaling pathways.

Strengths

• Includes data from 43 pediatric participants across four distinct clinical groups.
• Identifies seven specific miRNAs (e.g., miR-423-3p, miR-144-3p) with consistent expression patterns.
• Correlates miRNA findings with clinical and cytokine data.

Limitations

• The dataset is small at 22.4 KB, indicating limited scope and sample size.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

figshare

Collection Method

Cross-sectional study using whole blood samples and NanoString nCounter profiling.

Freshness

Last updated 2026-05-13 04:57:48; freshness should be verified.