CRIP1 Knockout and Single-Cell Transcriptomics Analysis of Immunometabolism

A 1.6 MB DOCX file presents integrated molecular insights into the CRIP1 gene's role in immunometabolism. The study analyzes liver tissues from CRIP1 knockout and wild-type mice, alongside single-cell RNA sequencing data from human peripheral mononuclear cells. Author DoYeon Kim published this work on figshare in March 2026 under a CC BY 4.0 license.

Use Cases

• Compare transcriptomic analysis results for zinc transport, iron metabolism, and oxidative phosphorylation between CRIP1 KO and WT mouse liver tissues.
• Analyze CRIP1 expression levels across diverse immune cell subsets from single-cell RNA sequencing data of healthy and periodontitis patients.
• Investigate the relationship between CRIP1 expression and inflammatory gene profiles, including pro-inflammatory and anti-inflammatory markers.
• Assess CRIP1-dependent changes in metabolic and immune responses under chronic low-grade inflammation induced by periodontal pathogens.

Strengths

• Data integrates findings from multiple experimental models: mouse knockout studies and human single-cell sequencing.
• Focuses on specific, under-explored biological areas: zinc transport, iron metabolism, and mitochondrial oxidative phosphorylation.
• Released under a permissive CC BY 4.0 license, facilitating reuse and redistribution.

Limitations

• The 1.6 MB size and DOCX format indicate the file contains a manuscript or summary, not a primary, structured dataset with rows and columns.
• No tabular data, sample records, or defined data schema (columns) are provided, limiting direct computational analysis.
• The description is speculative about future insights; the actual data presented may be limited to the study's specific figures and results.

Provenance

Source

figshare, authored by DoYeon Kim.

Collection Method

Experimental analysis of CRIP1 knockout mouse liver tissues and single-cell RNA sequencing of human peripheral mononuclear cells.

Time Range

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Freshness

Last updated March 2026.

Geography

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