Myasthenia Gravis and Anxiety-Depression: Clinical and Genetic Analysis

96 patient records from a retrospective clinical study show 62.5% of Myasthenia Gravis patients exhibited anxiety symptoms and 46.90% presented depressive symptoms. The dataset includes clinical scale scores and results from a bidirectional two-sample Mendelian Randomization analysis using European population genome-wide association studies. Author Lijun Luo published the data on figshare under a CC-BY-4.0 license, last updated in March 2026.

Use Cases

• Correlating disease severity (QMG score) with psychiatric symptom risk based on clinical findings.
• Investigating causal relationships between autoimmune and mental health conditions using Mendelian Randomization results.
• Analyzing the association between quality of life (MG-ADL score) and anxiety/depression in a patient cohort.

Strengths

• Clinical data from 96 patients with Myasthenia Gravis at initial diagnosis.
• Genetic analysis uses the largest and most recent European population GWAS for three phenotypes.
• Results include multiple sensitivity analyses and pleiotropy tests to validate robustness.

Limitations

• Dataset is very small at 40.5 KB, indicating limited scope.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to the European population GWAS sources.

Provenance

Source

figshare, author Lijun Luo.

Collection Method

Retrospective clinical analysis of patient records and Mendelian Randomization using GWAS data.

Freshness

Last updated 2026-03-18 05:34:53; freshness should be verified.

Geography

Clinical cohort location unspecified; genetic data from European populations.