Neonatal Jaundice and Gut Microbiome Data from a Case-Control Study in Xinjiang

A case-control study of term infants with pathologic jaundice and matched healthy controls. Stool samples were analyzed via shotgun metagenomic sequencing to assess microbial diversity, taxonomic composition, and functional gene repertoires. The dataset was uploaded by Muqing Niu on 2026-03-18.

Use Cases

• Train classification models to distinguish jaundiced from healthy infants based on microbial community structure.
• Analyze associations between specific microbial taxa (e.g., Escherichia coli, Bifidobacterium) and disease status.
• Investigate functional pathway enrichment (e.g., bile acid synthesis, carbohydrate metabolism) in the gut microbiome of jaundiced neonates.
• Perform Mendelian Randomization analyses to explore causal relationships between microbial metabolic pathways and jaundice risk.

Strengths

• Data includes functional gene repertoires and carbohydrate-active enzyme profiles derived from shotgun metagenomic sequencing.
• Analysis includes bidirectional Mendelian Randomization using publicly available GWAS summary statistics.
• Released under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset is small at 155.2 KB, indicating limited scope or summary-level data.
• Geographic coverage is specific to Xinjiang, which may limit generalizability.

Provenance

Source

figshare, uploaded by Muqing Niu.

Collection Method

Case-control study with stool samples subjected to shotgun metagenomic sequencing.

Freshness

Last updated 2026-03-18 07:36:16.

Geography

Xinjiang