Neural Stem Cell EV Protein Responses in Spinal Cord Injury Model

Protein expression data from an in vitro spinal cord injury model treated with neural stem cell-derived extracellular vesicles. The dataset likely contains measurements of apoptotic markers, cytoskeletal integrity proteins, and survival signaling pathway components collected 72 hours post-injury. The data was uploaded by Kristyna Sintakova under a CC-BY-4.0 license and last updated in June 2026.

Use Cases

• Analyze neuroprotective effects based on changes in apoptotic marker proteins
• Compare therapeutic potential based on protein expression from two neural stem cell sources (SPC-01 and iMR-90)
• Model signaling pathway modulation based on PTEN, STAT3, and Bcl-xL levels
• Assess cytoskeletal stability based on Nogo-A and RhoA protein measurements

Strengths

• Data is derived from a controlled in vitro model with defined treatment groups (control, SCI, SCI+sEVs)
• The dataset is associated with a detailed methodological description of sEV isolation and characterization
• File size is 447.2 KB, indicating a focused and likely manageable dataset

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• The study is limited to early injury responses (72 hours) in an in vitro model

Provenance

Source

figshare

Collection Method

Experimental data from spinal cord slice cultures analyzed via Western blot and other protein assays.

Freshness

Last updated 2026-06-03 04:47:34; freshness should be verified