Neuro-Ophthalmic Complications of Tuberculosis and Treatment: A Systematic Review

Twenty-two studies comprising 260,430 participants were analyzed to quantify neuro-ophthalmic complications of tuberculosis. The meta-analysis reports a pooled incidence of ethambutol optic neuropathy at 1.54% and identifies renal impairment and hypertension as significant risk factors. Ahmed A. Alessa published this systematic review on figshare in May 2026 under a CC-BY-4.0 license.

Use Cases

• Estimating the incidence of ethambutol optic neuropathy based on the pooled 1.54% rate from the meta-analysis.
• Identifying risk factors for neuro-ophthalmic complications based on reported odds ratios for renal impairment and hypertension.
• Comparing diagnostic efficacy for subclinical changes based on the reported superior performance of visual evoked potentials over optical coherence tomography.
• Assessing visual recovery outcomes in clinical cases based on the reported 52.4% recovery rate and associated factors like age and treatment timing.

Strengths

• Analysis is based on 22 studies with a total of 260,430 participants, providing a substantial evidence base.
• Reports specific, quantified findings such as a 1.54% pooled incidence of ethambutol optic neuropathy and odds ratios for risk factors.
• Follows PRISMA 2020 guidelines for systematic review conduct, suggesting a structured methodology.

Limitations

• The dataset is a 16.1 KB DOCX document, which is a summary report; the underlying raw data or column-level details are not provided.
• Row count and column definitions are unknown, limiting direct analysis of the primary data.
• The data reflects findings aggregated from literature up to September 2025 and may not include more recent studies.

Provenance

Source

Ahmed A. Alessa via figshare.

Collection Method

Systematic review and meta-analysis following PRISMA 2020 guidelines, searching multiple databases (PubMed, Scopus, Embase, etc.).

Time Range

Literature search up to 2025-09-30.

Freshness

Last updated 2026-05-29 04:44:46; literature search current up to 2025-09-30.