NGF Administration Effects on GnRH and Hormone Levels in Aging Mice

6.8 MB of experimental data from a study on nerve growth factor (NGF) administration in male SAMP8 mice. The dataset, uploaded by Jiao Luo on figshare in April 2026, includes measurements of serum hormones (LH, FSH, testosterone) and phenotypic readouts related to gonadotropin-releasing hormone (GnRH) neurons. It was generated to explore NGF's role in promoting a GnRH-associated phenotype in hypothalamic neural stem cells.

Use Cases

• Analyze the time-course effects of NGF on serum hormone levels based on measurements taken at 8h, 24h, 96h, 7d, and 10d post-injection.
• Investigate the relationship between NGF administration and GnRH immunoreactivity based on phenotypic readouts from the organum vasculosum of the lamina terminalis (OVLT).
• Study the differentiation of hypothalamic neural stem cells (htNSCs) into a GnRH-secreting neuroendocrine phenotype based on in vitro culture results.
• Examine signaling pathways involved in NGF-induced effects based on transcriptomic profiling and quantitative PCR data mentioned in the description.

Strengths

• Data is associated with a detailed experimental methodology described in the purpose, methods, and results sections.
• The dataset is licensed under CC-BY-4.0, allowing for open sharing and reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The dataset's 6.8 MB size suggests it is relatively small in scale.

Provenance

Source

figshare, uploaded by Jiao Luo.

Collection Method

Experimental data from in vivo mouse models and in vitro three-dimensional cell culture, as described in the methods.

Freshness

Last updated 2026-04-24 05:40:47; freshness should be verified.