Meta-Analysis of Cetuximab Maintenance Therapy in Metastatic Colorectal Cancer

Yici Yan's systematic review and meta-analysis, published on figshare in June 2026, aggregates data from 6 studies involving 727 patients. It assesses the efficacy and safety of cetuximab maintenance therapy for metastatic colorectal cancer, analyzing progression-free survival, overall survival, and adverse effects. The document includes pooled hazard ratios and relative risks from a literature search covering PubMed, Embase, Cochrane Library, and Scopus.

Use Cases

• Conducting secondary analysis of survival outcomes based on pooled hazard ratios for PFS and OS.
• Evaluating treatment safety profiles based on the relative risks of all-grade and high-grade adverse effects.
• Investigating demographic treatment efficacy based on subgroup analysis results for Asian patients.

Strengths

• Includes data from 6 studies with a total of 727 patients.
• Reports specific hazard ratios with 95% confidence intervals for PFS (HR: 0.42) and OS (HR: 0.47).
• Registered with PROSPERO (CRD42024513879), indicating a structured review protocol.

Limitations

• The dataset is a 13.5 KB DOCX file, suggesting limited raw data and primarily a summary document.
• Row and column-level data are unknown, requiring manual inspection after download to assess underlying data structure.
• The description does not specify the temporal range of the included primary studies.

Provenance

Source

Yici Yan via figshare.

Collection Method

Systematic literature review and meta-analysis of studies from PubMed, Embase, Cochrane Library, and Scopus.

Time Range

Literature search from database inception to March 2026.

Freshness

Last updated 2026-06-03 06:10:57.