Peripheral CD4+ Naïve T Cell and MMP1 Signatures in Acute Gouty Arthritis

A 98.9 KB Excel file containing data from a multi-modal study of acute gouty arthritis. The dataset likely includes results from Mendelian randomization, mass cytometry, single-cell RNA-seq re-analysis, and plasma proteomics from Chinese cohorts. It was authored by Peng Zhang and last updated on 2026-05-26.

Use Cases

• Validate genetic associations between immune cell phenotypes and gout risk based on Mendelian randomization results.
• Analyze peripheral immune cell remodeling during acute flares based on CyTOF and single-cell RNA-seq data.
• Assess the exploratory potential of plasma MMP1 and S100A12 levels for recurrence risk stratification.
• Investigate predicted cell-cell communication pathways, such as MIF–CXCR2 and ANXA1–FPR1 signaling, in acute gout.

Strengths

• Data integrates results from multiple analytical methods: bidirectional Mendelian randomization, CyTOF, single-cell RNA-seq, and plasma proteomics.
• Includes data from specific cohort sizes: CyTOF analysis used samples from 25 GA-A, 22 GA-R, and 9 healthy control patients.
• Plasma proteomic validation involved independent training (n=40) and validation (n=64) cohorts.
• Reported an exploratory AUC of 0.8533 for MMP1 in 12-week recurrence risk stratification within a subgroup.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• The dataset is small at 98.9 KB, indicating it likely contains summary results rather than raw, high-dimensional data.
• Description metadata is limited; actual data quality and structure require verification.

Provenance

Source

figshare, authored by Peng Zhang.

Collection Method

Data likely generated from integrated analyses including Mendelian randomization, mass cytometry (CyTOF), single-cell RNA-seq re-analysis, and Olink plasma proteomics.

Freshness

Last updated 2026-05-26 06:03:53; freshness should be verified.

Geography

Genetic data from European ancestry GWAS; clinical cohorts described as Chinese.