Table 3_Placental transcriptome profiling in congenital Chagas disease: gene networks asso

Transcriptomic analysis of placental tissues from deliveries of congenitally infected, exposed but uninfected, and unexposed/uninfected newborns. The dataset, authored by Sofia Apodaca and last updated in March 2026, identifies differential gene expression and altered pathways associated with Trypanosoma cruzi transmission. It includes findings on genes like CEMIP, PRRX1, and CGB5, and results from gene set and cell type enrichment analyses.

Use Cases

• Identify biomarkers for congenital Chagas disease transmission based on differential gene expression of CEMIP, PRRX1, and CADM3.
• Investigate the role of extracellular matrix and cell adhesion pathways in placental barrier function using Gene Ontology enrichment results.
• Analyze cell type-specific transcriptional responses by examining enrichment patterns for trophoblast subtypes.
• Validate co-expression network models of placental signaling using identified hub genes ENPP1 and SLC16A10.

Strengths

• Data is derived from a controlled transcriptomic study comparing three distinct clinical groups (M+B+, M+B−, M−B−).
• Analysis includes multiple methodologies: differential gene expression, gene set enrichment, cell type enrichment, and co-expression network analysis.
• Dataset is openly licensed under CC-BY-4.0, permitting reuse with attribution.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• The dataset is small (42.8 KB), indicating it likely contains summary results rather than raw sequencing data.

Provenance

Source

Sofia Apodaca via figshare

Collection Method

RNA-seq transcriptomic analysis of placental tissues from clinical deliveries.

Freshness

Last updated 2026-03-18 06:43:05