Plasma Proteome Mendelian Randomization for Gastric Cancer Drug Targets

13 ancestry-specific plasma protein targets for gastric cancer identified through Mendelian randomization analysis. The dataset includes four significant targets in European populations and nine in East Asian populations, with experimental validation for two candidates. Author Peng Zhi published the data on figshare in 2026 under a CC-BY-4.0 license.

Use Cases

• Prioritize drug targets for gastric cancer based on ancestry-specific protein associations identified in the study
• Validate causal protein-disease links using Mendelian randomization results across European and East Asian populations
• Identify repurposable drugs through molecular docking results, such as digoxin for cross-ancestry therapy
• Investigate cellular expression patterns of candidate proteins in epithelial and Pit mucous cells from gastric tumor tissue

Strengths

• Identifies 13 specific protein targets, including five novel candidates, for gastric cancer.
• Provides multi-ancestry analysis comparing European and East Asian populations.
• Includes experimental validation for NME4 and ICAM5 protein expression in cell lines and tissue samples.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect bias inherent to the specific proteomic studies and Mendelian randomization methodology used.

Provenance

Source

figshare

Collection Method

Mendelian randomization and colocalization analysis of plasma proteome data across populations, followed by single-cell RNA sequencing, molecular docking, and experimental validation.

Freshness

Last updated 2026-05-01 04:19:29

Geography

European and East Asian populations