Platycodin D Effects on Cardiac Hypertrophy and Apoptosis Signaling in Mice

A 667.7 KB Excel dataset from figshare details the therapeutic effects of Platycodin D on heart failure in a mouse model. Yingrui Li's study, last updated in 2026, includes results from administering doses of 12.5, 25, or 50 mg/kg/d for 4 weeks. The data likely contains measurements related to cardiac function, hypertrophy, and the p53-dependent BCL-2/Bax/caspase-3 signaling pathway.

Use Cases

• Modeling dose-response relationships for Platycodin D based on the described 12.5-50 mg/kg/d administration.
• Analyzing correlations between p53 pathway inhibition and cardiac function metrics mentioned in the study.
• Comparing therapeutic effects of Platycodin D with the p53 inhibitor pifithrin-α as described in the results.

Strengths

• Specific experimental details are provided, including three drug doses (12.5, 25, 50 mg/kg/d) and a 4-week treatment period.
• The dataset is shared under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small at 667.7 KB, indicating a limited scope of data.

Provenance

Source

figshare

Collection Method

Data likely originates from a controlled laboratory study using an isoprenaline-induced heart failure mouse model.

Freshness

Last updated 2026-05-26 06:03:52; freshness should be verified.