BNT162b2 Vaccine Proteomic Changes Over 6 Months in Qatar

354 plasma proteins were quantified using Olink technology in 70 healthy individuals before and after a third BNT162b2 mRNA vaccine dose. The longitudinal study tracked protein levels at 3- and 6-months post-booster, comparing infection-naïve and previously infected cohorts. Results highlight sustained changes in proteins like PARP-1 and MMP-7.

Use Cases

• Analyze longitudinal protein expression changes based on the 354 quantified plasma proteins.
• Compare post-booster proteomic profiles based on prior infection status.
• Identify sustained inflammatory biomarkers based on highlighted proteins like PARP-1 and MMP-7.
• Study temporal dynamics of immune response based on measurements at 3- and 6-months post-booster.

Strengths

• 354 unique proteins were quantified per sample.
• 70 individuals were studied, split into infection-naïve and previously infected cohorts.
• Data includes longitudinal measurements at three time points: pre-booster, 3-months, and 6-months post-booster.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (10.5 KB), indicating limited scope.

Provenance

Source

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Collection Method

Plasma levels of proteins were quantified using Olink technology.

Time Range

The study tracked individuals for 6 months post-booster.

Freshness

Last updated 2026-04-24 05:37:11; freshness should be verified.

Geography

Data was collected from individuals in Qatar.