Systematic Review and Meta-Analysis of Nutrition-Based Prognostic Indices in Breast Cancer

A meta-analysis aggregating results from 32 reports comprising 13,120 individuals with breast cancer, published by Si Chen in 2026. It evaluates the prognostic utility of the Prognostic Nutritional Index (PNI) and Controlling Nutritional Status (CONUT) score for predicting overall survival, disease-free survival, and pathological complete response. The analysis was conducted using data from PubMed, Embase, Web of Science, and Cochrane Library up to October 2025.

Use Cases

• Evaluating the association between Prognostic Nutritional Index (PNI) and overall survival in breast cancer patients.
• Assessing the link between Controlling Nutritional Status (CONUT) score and disease-free survival.
• Investigating the relationship between PNI and pathological complete response (pCR) rates.
• Conducting subgroup analyses and meta-regression to explore heterogeneity in prognostic studies.

Strengths

• Aggregates data from 32 reports and 13,120 individuals, providing a substantial evidence base.
• Reports pooled hazard ratios and odds ratios with 95% confidence intervals for multiple clinical outcomes.
• Includes subgroup analyses, meta-regression, and 95% prediction intervals to assess heterogeneity.

Limitations

• The dataset is a 12.5 KB DOCX document containing a review article, not a primary data table.
• Column-level documentation and sample data are unavailable, limiting direct analysis of the underlying studies.
• Prediction intervals for several analyses crossed the null value, indicating substantial between-study variability.

Provenance

Source

figshare

Collection Method

Systematic review and meta-analysis of studies from PubMed, Embase, Web of Science, and Cochrane Library.

Time Range

Studies from database inception to 20 October 2025.

Freshness

Last updated 2026-05-11 04:17:54.