Preoperative Malnutrition, Tumor Immunity, and Microbiota in 43 Colorectal Cancer Patients

Federica Perillo's prospective pilot study includes data from 43 colorectal cancer patients who underwent resection surgery between July 2017 and August 2021 at IRCCS Ca′ Granda Ospedale Maggiore Policlinico in Milan. The dataset contains biochemical, anthropometric, and nutritional profiles, intratumoral immune phenotypes, and tumor-associated microbiota analysis for a subset of 8 patients. It was last updated on 2026-05-28 and is shared under a CC-BY-4.0 license.

Use Cases

• Analyze the association between malnutrition screening scores (MUST) and altered T cell phenotypes based on the described immune profiling.
• Investigate correlations between neutrophil lymphocyte ratio (NLR) and specific bacterial genera (Bacteroides, Prevotella, Parabacteroides) mentioned in the microbiota analysis.
• Model the relationship between preoperative nutritional status and intratumoral immune cell infiltration, such as tissue-infiltrating neutrophils.
• Explore potential biomarkers linking gut microbiota composition to suppressed anti-tumor immunity in malnourished colorectal cancer patients.

Strengths

• Prospective study design with 43 enrolled patients, providing a defined cohort.
• Multimodal data collection includes biochemical, anthropometric, nutritional, immune phenotype, and microbiota profiles.
• Specific time range (July 2017 to August 2021) and hospital location (Milan) are documented.

Limitations

• Tumor-associated microbiota analysis was performed on a very small subset of only 8 patients.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 18.3 KB, indicating limited scope and likely summary-level data.

Provenance

Source

Federica Perillo, likely affiliated with IRCCS Ca′ Granda Ospedale Maggiore Policlinico, Milan.

Collection Method

Prospective clinical pilot study; data gathered from patient evaluations and sample analysis.

Time Range

July 2017 to August 2021

Freshness

Last updated 2026-05-28 15:37:39; freshness should be verified.

Geography

Milan, Italy