Metformin-Associated Erythema Multiforme Case Report and Causality Assessment

A single clinical case report authored by Long Luo, published on figshare under a CC-BY-4.0 license. The report describes a 51-year-old male patient who developed erythema multiforme ten days after initiating metformin therapy for type 2 diabetes. This is the second such case reported in English literature since 2004, providing a practical reference for causality assessment in polypharmacy settings.

Use Cases

• Assessing causality of drug-induced skin reactions based on the detailed timeline and rechallenge protocol described
• Studying rare adverse event phenotypes for metformin based on the documented clinical presentation
• Developing differential diagnosis frameworks for polypharmacy patients based on the case's structured approach

Strengths

• Provides a detailed timeline of drug initiation and symptom onset (10 days)
• Includes a structured drug rechallenge process to identify the causative agent
• Offers a specific causality assessment ('probable') for the adverse event

Limitations

• Dataset consists of a single case report, limiting statistical generalizability
• Row count and column-level documentation are absent, requiring manual inspection of the document
• The 17.4 KB file size indicates a very limited scope, containing primarily narrative text

Provenance

Source

figshare

Collection Method

Clinical case documentation

Freshness

Last updated 2026-05-14 14:22:02