Meta-Analysis of Neutrophil-to-Lymphocyte Ratio and Breast Cancer Outcomes

A systematic review and meta-analysis of 56 studies involving 16,539 breast cancer patients. The study synthesized pooled hazard ratios and odds ratios to examine the relationship between pretreatment neutrophil-to-lymphocyte ratio (NLR) and survival outcomes or treatment response. The dataset was published by Ziqian Zhao on figshare in May 2026.

Use Cases

• Training prognostic models based on aggregated hazard ratios for overall survival, disease-free survival, and recurrence-free survival.
• Analyzing the association between a pretreatment biomarker and pathologic complete response rates based on synthesized odds ratios.
• Conducting sensitivity analyses on multivariable-adjusted estimates for biomarker stability.

Strengths

• Aggregates data from 56 studies, providing a substantial evidence base.
• Includes results for 16,539 individual patients.
• Reports specific pooled hazard ratios and odds ratios with 95% confidence intervals and p-values.

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (20.6 KB), indicating limited scope, likely containing summary statistics rather than patient-level data.

Provenance

Source

figshare, author Ziqian Zhao.

Collection Method

Systematic review and meta-analysis of studies from PubMed, EMBASE, Web of Science, and the Cochrane Library.

Time Range

Studies published up to April 2026.

Freshness

Last updated 2026-05-29 04:52:35; freshness should be verified.