Meta-Analysis of Neutrophil-to-Lymphocyte Ratio and Breast Cancer Outcomes

Fifty-six studies involving 16,539 patients were synthesized to examine the prognostic value of the pretreatment neutrophil-to-lymphocyte ratio (NLR) in breast cancer. The meta-analysis, authored by Ziqian Zhao and published on figshare in May 2026, found elevated NLR was significantly associated with worse survival outcomes and lower rates of pathologic complete response. The dataset is a 20.6 KB document containing the aggregated statistical results from this systematic review.

Use Cases

• Validate the association between hematological markers and cancer survival based on pooled hazard ratios.
• Assess the relationship between neutrophil-to-lymphocyte ratio and treatment response based on odds ratios for pathologic complete response.
• Inform the design of prospective clinical studies on complementary prognostic markers based on the meta-analysis conclusions.

Strengths

• Aggregates data from 56 studies and 16,539 patients, providing a substantial evidence base.
• Reports specific pooled hazard ratios and odds ratios with 95% confidence intervals and p-values.
• Includes sensitivity analyses restricted to multivariable-adjusted estimates, as noted in the description.

Limitations

• The dataset is a 20.6 KB document; the underlying tabular data for the meta-analysis is not directly provided.
• Column-level documentation is absent; field semantics must be inferred from the manuscript.
• Substantial heterogeneity and inconsistent cutoffs for NLR are noted as limitations in the original conclusion.

Provenance

Source

figshare, author Ziqian Zhao.

Collection Method

Systematic review and meta-analysis of studies from PubMed, EMBASE, Web of Science, and the Cochrane Library.

Time Range

Studies published up to April 2026.

Freshness

Last updated 2026-05-29 04:52:35.