MAIT Cell Alterations in Sepsis-Related Liver Injury from Clinical and Murine Studies

47 sepsis-related liver injury patients, 37 non-septic acute liver injury patients, 34 sepsis patients without liver injury, and 115 healthy controls were analyzed for mucosal-associated invariant T cell frequency and phenotype. The study, authored by Wei Bu and last updated in April 2026, includes flow cytometry data and in vitro assays showing MAIT cells shift toward a Th17-like profile. A murine model using LPS injection further demonstrated the protective role of MAIT cells in mitigating liver injury severity.

Use Cases

• Modeling the relationship between bilirubin levels and MAIT cell activation/exhaustion based on described in vitro assays
• Analyzing immune cell phenotypic shifts (CD69+, PD-1+, CD25+, Tim-3+) in sepsis cohorts described in the results
• Investigating the protective role of MAIT cells in liver injury using the described murine LPS injection model

Strengths

• Includes data from a defined clinical cohort of 233 total subjects (47 SRLI, 37 NSLI, 34 NLIS, 115 HC)
• Combines human clinical data with controlled murine model experiments for validation
• License is CC-BY-4.0, permitting open sharing and adaptation

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The primary data file is a 12.6 KB DOCX document, suggesting limited raw data or that it is primarily a manuscript

Provenance

Source

figshare, author Wei Bu

Collection Method

Clinical cohort analysis and murine model experiments, as described in the methods section.

Time Range

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Freshness

Last updated 2026-04-15 05:44:19; freshness should be verified

Geography

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