Quercetin Effects on Skin Inflammation and Fibrosis in Systemic Sclerosis

Xiangzhen Kong authored a research document detailing the effects of quercetin on systemic sclerosis. The document, last updated in June 2026, describes a study using primary CD4+ T cells from patients and a bleomycin-induced mouse model. The findings suggest quercetin targets the RELA/c-Jun axis to suppress Th17 cell responses and alleviate skin fibrosis.

Use Cases

• Identify potential drug targets for Th17-mediated diseases based on the described RELA/c-Jun axis.
• Study the immunomodulatory effects of flavonoids like quercetin based on the described cytokine suppression.
• Validate molecular binding assays such as DARTS and CETSA based on the described methodology.
• Investigate skin fibrosis mechanisms in systemic sclerosis based on the described in vivo model results.

Strengths

• The document provides a detailed mechanistic explanation of quercetin's action.
• Research methods like DARTS and CETSA are explicitly named for validation.
• The data is shared under a CC-BY-4.0 license, allowing for reuse.

Limitations

• The dataset is a 14.5 KB DOCX file, indicating a limited scope likely focused on textual results.
• Row count and column-level documentation are absent, requiring manual inspection after download.
• The data may reflect the specific experimental bias inherent to the described lab study.

Provenance

Source

Xiangzhen Kong via figshare

Collection Method

Laboratory research using primary CD4+ T cells and a bleomycin-induced mouse model.

Freshness

Last updated 2026-06-03 05:16:38; freshness should be verified.