Mendelian Randomization Study Linking Immune Cells and Metabolites to Liver Cancer Risk

A genetic analysis dataset from a two-sample Mendelian randomization study investigating causal links between immune cell profiles, blood metabolites, and intrahepatic cholangiocarcinoma. The dataset includes results identifying three specific immune traits as risk factors and two metabolites as potential mediators, with supporting in vitro experimental validation. The dataset was authored by Zhipeng Ye and last updated on 2026-05-22.

Use Cases

• Validate causal relationships between immune phenotypes and cancer risk based on Mendelian randomization results
• Investigate the role of N-acetylleucine and fructosyllysine as metabolic mediators in cancer pathways
• Design experimental follow-ups targeting the DLAT-leucine metabolic axis in cancer cell lines
• Perform sensitivity analyses for genetic studies to account for horizontal pleiotropy and heterogeneity

Strengths

• Includes specific odds ratios and confidence intervals for three identified immune cell risk factors (e.g., OR = 1.0005 for activated CD4 regulatory T cells)
• Employs a two-sample Mendelian randomization method with sensitivity analyses to address confounding
• Provides experimental validation from in vitro studies on HuCC-T1 and RBE cells

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is small (245.4 KB), indicating limited scope, likely containing summary results rather than raw genetic data

Provenance

Source

figshare

Collection Method

Two-sample Mendelian randomization analysis with mediation analysis and in vitro experimental validation.

Freshness

Last updated 2026-05-22 06:10:29; freshness should be verified