Danggui Sini Granule Effects on Gut Microbiota and Metabolites in Vasospastic CHD Rats

A research document from figshare, authored by Haipeng Tang and last updated in May 2026, details a multi-omics study on a rat model of coronary heart disease. The study investigates the cardioprotective mechanisms of Danggui Sini Granule by profiling gut microbial alterations via 16S rRNA sequencing and serum metabolic changes via untargeted metabolomics. The 39.8 KB document integrates pharmacodynamic evaluations with network pharmacology and molecular docking analyses.

Use Cases

• Study gut microbiota remodeling in cardiovascular disease based on 16S rRNA sequencing data mentioned in the description
• Analyze metabolic pathway disturbances in CHD based on untargeted metabolomics profiling of linoleic and arachidonic acid pathways
• Validate predicted drug-target interactions based on molecular docking results for components like Quercetin and PGE1
• Investigate correlations between inflammatory markers (TNF-α, IL-6) and microbial shifts based on integrated pharmacodynamic and omics data

Strengths

• Integrates multiple data modalities: pharmacodynamics, 16S rRNA sequencing, and untargeted metabolomics.
• Includes results from molecular docking simulations for key components and metabolites.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• The dataset is a 39.8 KB DOCX file, suggesting limited raw data is included; likely contains summarized results and analysis.
• Row count and column-level documentation are absent; field semantics must be inferred after download.
• Data is from a specific rat model; applicability to human physiology is uncertain.

Provenance

Source

figshare, author Haipeng Tang.

Collection Method

Data generated from a rat model of vasospastic CHD, with gut microbiome profiling via 16S rRNA sequencing and serum analysis via untargeted metabolomics.

Freshness

Last updated 2026-05-22 04:28:08.