Retinoic Acid Antiviral Effects on PRRSV Infection in Swine Cells

Transcriptomic data from a study evaluating all-trans retinoic acid (ATRA) against porcine reproductive and respiratory syndrome virus (PRRSV) in MARC-145 cells and primary porcine alveolar macrophages (PAMs). The dataset includes results from antiviral efficacy assays and comparative transcriptomic profiling of infected and uninfected cells. Author Jintong Guo published the data under a CC BY 4.0 license in March 2026.

Use Cases

• Analyze transcriptomic profiles to identify ATRA-upregulated immune signaling pathways in uninfected PAMs.
• Compare gene expression data between PRRSV-infected and ATRA-treated PAMs to study the reversal of hyperinflammatory responses.
• Investigate transcriptomic data on lipid homeostasis to understand ATRA's role in restoring cellular metabolic balance during PRRSV infection.

Strengths

• Data originates from a controlled laboratory study evaluating a specific antiviral compound (ATRA) against PRRSV.
• Includes transcriptomic profiling from two relevant cell models: MARC-145 cells and primary porcine alveolar macrophages (PAMs).
• Dataset is openly available under a permissive CC BY 4.0 license.

Limitations

• The dataset is small in scale at 612.3 KB, indicating limited raw data volume for extensive secondary analysis.
• Sample data and column structure are unavailable, complicating assessment of data format and variables.
• Data is derived from in vitro cell studies, limiting direct applicability to in vivo or field conditions.

Provenance

Source

Jintong Guo via figshare.

Collection Method

Generated from laboratory experiments including antiviral assays and RNA sequencing (RNA-Seq) transcriptomic profiling.

Freshness

Last updated March 2026.