Retrospective Analysis of Vagus Nerve Stimulation for mTBI with PTSD Symptoms

A post-hoc subgroup analysis of a retrospective cohort study on adjunctive non-invasive vagus nerve stimulation (nVNS) for chronic mild traumatic brain injury (mTBI) with comorbid PTSD. The dataset, authored by Michael Ament and last updated in April 2026, likely contains Neurobehavioral Symptom Inventory (NSI) scores at baseline and follow-up for a PTSD-enriched subgroup. Results show a significant mean reduction in total NSI score from 2.50 to 2.03 after 3–4 months of treatment.

Use Cases

• Analyze symptom domain improvements (affective, cognitive, somatic, vestibular) based on NSI scores mentioned in the description.
• Identify high-symptom-burden patient phenotypes based on multivariate analysis results described.
• Model treatment response rates based on the reported 40% of patients achieving a ≥30% symptom reduction.
• Compare baseline symptom profiles between patient subgroups (PTSD+ vs. PTSD-) as referenced in the methods.

Strengths

• Includes statistically significant results with FDR-corrected p-values (q < 0.05) reported for symptom changes.
• Provides specific mean NSI scores (2.50 ± 0.60 baseline, 2.03 ± 0.46 follow-up) and domain-level reductions.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is contained in a DOCX file (15.1 KB), suggesting a small, likely summary-level table rather than raw patient-level data.

Provenance

Source

Michael Ament via figshare.

Collection Method

Post-hoc analysis of a previously published retrospective observational cohort.

Time Range

Treatment and follow-up period of 3–4 months, as per the study methods.

Freshness

Last updated 2026-04 13 05:44:22; freshness should be verified.

Geography

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