YWHAZ RNA-Binding Protein Data: Gene Expression and Binding Targets in Diabetic Foot Ulcer

A 219.5 KB Excel file published by Tianjian Zha on figshare in May 2026. It contains results from a study investigating the RNA-binding protein YWHAZ in diabetic foot ulcer tissues, including differentially expressed genes and binding targets identified via RNA-seq and iRIP-seq.

Use Cases

• Identify potential YWHAZ binding motifs based on the reported GC-rich sequence preference.
• Analyze the functional enrichment of 1,072 differentially expressed genes from YWHAZ-knockdown experiments.
• Investigate the role of the 57 selectively bound DEGs, such as SREBF1, in insulin resistance pathways.
• Validate cellular proliferation and apoptosis markers like AREG, FOSL1, and LAMB3 in the context of diabetic wound healing.

Strengths

• Includes results from multiple experimental methods (RT-qPCR, RNA-seq, iRIP-seq) for cross-validation.
• Identifies 1,072 differentially expressed genes and 57 specific mRNA targets of YWHAZ.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Row count and column-level documentation are absent; field semantics must be inferred after download.
• The 219.5 KB file size suggests a limited scope, likely containing summary results rather than raw sequencing data.

Provenance

Source

figshare, author Tianjian Zha.

Collection Method

Generated from laboratory experiments including RNA sequencing and improved RNA immunoprecipitation.

Freshness

Last updated 2026-05-07 04:47:35; freshness should be verified.