Table 3_S-ketamine mitigates paclitaxel-induced pain-related anxiety-like behavior through

780.2 KB of data from a study by Jing Cao, last updated April 2026, investigating S-ketamine's effects on paclitaxel-induced neuropathic pain and anxiety in mice. The dataset likely contains behavioral test results, electrophysiological recordings, and molecular expression levels from the prelimbic cortex. Findings suggest S-ketamine mitigates symptoms via downregulation of mGluR5 and activation of the BDNF/TrkB pathway.

Use Cases

• Modeling the relationship between mechanical allodynia and anxiety-like behaviors based on behavioral test results.
• Analyzing correlations between pyramidal neuron firing rates and mGluR5 expression levels in the prelimbic cortex.
• Investigating the BDNF/TrkB signaling pathway's role in mitigating chemotherapy side effects based on protein expression data.

Strengths

• Data integrates behavioral, electrophysiological, and molecular dimensions from a controlled mouse model.
• The study design includes specific tests like the electronic von Frey test and elevated plus maze, suggesting structured measurements.
• License is CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small at 780.2 KB, indicating limited scope.

Provenance

Source

figshare, author Jing Cao

Collection Method

Data generated from a laboratory study involving intraperitoneal paclitaxel injection in mice, followed by behavioral tests, electrophysiological recordings, immunofluorescence, and Western blotting.

Freshness

Last updated 2026-04-23 05:36:34; freshness should be verified.