Systematic Review of S100 Proteins in IgA Vasculitis Studies

A 2025 systematic review synthesized evidence from 54 human studies on S100 proteins in vasculitis. The dataset compiles findings on S100A8/9, S100A12, S100A4, and S100A10 proteins from a PRISMA-compliant search of PubMed, Embase, Scopus, and Web of Science. It was authored by Zofia Podraza to evaluate the mechanistic and clinical roles of these proteins, particularly in IgA vasculitis.

Use Cases

• Analyze the association between S100A8/9 protein levels and neutrophil-driven inflammation markers across the 54 included studies.
• Compare evidence for S100A12 as a biomarker of disease activity in IgA vasculitis versus other systemic vasculitides.
• Assess the fragmentary findings on S100A4 and S100A10 to identify gaps for future IgAV-specific research.
• Synthesize data on Calprotectin (S100A8/9) and Calgranulin C (S100A12) to evaluate their potential for clinical risk stratification.

Strengths

• Includes 54 original human studies identified through a systematic, PRISMA-compliant literature review.
• Focuses on four specific S100 protein families (S100A8/9, S100A12, S100A4, S100A10) with defined biological roles.
• Compiled by a named author (Zofia Podraza) and published under a permissive CC BY 4.0 license.

Limitations

• The dataset is small (34.7 KB), indicating it is a summary or extracted data table, not the full-text studies.
• Findings for S100A4 and S100A10 are described as fragmentary and indirect, lacking sufficient IgAV-specific data.
• Temporal coverage is limited to studies published up to November 2025, potentially missing newer evidence.

Provenance

Source

Systematic review of studies from PubMed, Embase, Scopus, and Web of Science.

Collection Method

PRISMA-compliant systematic search and narrative data synthesis following independent risk-of-bias assessment.

Time Range

Literature search conducted up to November 18, 2025.

Freshness

Last updated on March 25, 2026.

Geography

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