Serum Steroid Hormone Profiles in Reproductive-Age Women with Systemic Lupus Erythematosus

Xiaotong Chen's dataset contains serum steroid hormone measurements from a cross-sectional study of 39 newly diagnosed, treatment-naïve female SLE patients and 37 matched healthy controls. Hormone levels, including glucocorticoids, mineralocorticoids, androgens, estrogens, and progestogens, were quantified using LC-MS/MS and correlated with clinical parameters and disease activity scores. The dataset was last updated on April 22, 2026.

Use Cases

• Identify hormonal biomarkers associated with SLE disease activity based on measured steroid hormone levels.
• Investigate correlations between specific hormone deficiencies (e.g., aldosterone) and clinical manifestations like proteinuria.
• Compare steroid hormone profiles across menstrual phases in SLE patients versus healthy controls.
• Analyze associations between adrenal/gonadal steroid levels and inflammatory markers such as IL-6 and complement levels.

Strengths

• Data is from a controlled study with 39 SLE patients and 37 matched healthy controls.
• Hormone quantification uses a precise method (liquid chromatography-tandem mass spectrometry).
• Clinical parameters and disease activity scores (SLEDAI-2000) are assessed alongside hormone levels.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The sample size of 39 patients is relatively small for broad generalization.

Provenance

Source

Xiaotong Chen via figshare

Collection Method

Cross-sectional study with fasting blood samples collected in the morning from enrolled participants.

Freshness

Last updated 2026-04-22 05:49:33; freshness should be verified.