Sex-Dependent Transcriptomic and Epigenomic Profiles of Neutrophils in COPD

Sex represents a major source of transcriptional variation in neutrophils from COPD patients, according to integrated transcriptomic and epigenomic profiling. The dataset, authored by Barbara Mariotti and last updated in May 2026, likely contains results comparing male and female inflammatory programs. Male COPD neutrophils showed robust enrichment of interferon signaling and inflammatory networks, while female neutrophils preferentially exhibited programs related to autophagy.

Use Cases

• Identify sex-specific gene expression signatures in COPD based on the described transcriptomic profiles.
• Analyze epigenetic regulation differences via H3K27ac enrichment data mentioned in the description.
• Investigate correlations between neutrophil transcriptional programs and plasma inflammatory mediators like CXCL8 and TNF-α.
• Compare disease-associated transcriptional frameworks between sexes as described in the results.

Strengths

• Data integrates transcriptomic and epigenomic profiling from a specific cell type (circulating neutrophils).
• Analysis includes specific plasma inflammatory mediators: CXCL8, TNF-α, IFN-α, IFN-γ, and VEGF.
• Dataset is licensed under CC-BY-4.0, permitting open sharing and adaptation.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is small at 53.1 KB, indicating limited scope or summary-level data.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare, author Barbara Mariotti

Collection Method

Transcriptomic and epigenomic profiling of circulating neutrophils from male and female COPD patients.

Freshness

Last updated 2026-05-27 20:01:59; freshness should be verified.